The development of Sativex® — a natural cannabis-based medicine

摘要: Cannabis has been used medicinally for 4000 years [1–4] in a variety of cultures and was re-introduced into British medicine 1842 by W. O’Shaughnessy [5]. It remained the pharmacopaeia until 1932, when cannabis, extract cannabis tincture were among 400 medicines removed, though all three Pharmaceutical Codex 1949 However, following 1961 UN Single Convention on Narcotic Drugs, derivatives became scheduled products subject to special measures control parties could ban their use altogether. Following 1971 Psychotropic Substances, UK enacted Misuse Drugs Act 1971. Cannabinol its derivatives, including ∆-tetrahydrocannabinol (∆-THC), appeared Schedule I Convention, regular medical prohibited. The introduction Regulations 1973 listed 4 (now current legislation), thereby prohibiting altogether