Glutathione depletion in nigrostriatal slice cultures: GABA loss, dopamine resistance and protection by the tetrahydrobiopterin precursor sepiapterin
作者： Jan Bert Gramsbergen , Mats Sandberg , Annette Møller Dall , Brian Kornblit , Jens Zimmer
DOI: 10.1016/S0006-8993(02)02451-4
关键词:
摘要: Dopaminergic neurons in culture are preferentially resistant to the toxicity of glutathione (GSH) depletion. This effect may be due high intrinsic levels tetrahydrobiopterin (BH ). Here we studied effects manipulating GSH and / or BH on selective 4
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