Reduced Pterins as Scavengers for Reactive Oxygen Species

摘要: Pterins are widely distributed in nature three forms: tetrahydro, dihydro, and oxidized. The most studied pterin is L-erythro-5,6,7,8-tetrahydrobiopterin (BH4), the electron donor for mixed function oxidases, such as Phe hydroxylase during conversion of to Tyr, Tyr Trp hydroxylases biogenic amine synthesis.1 BH4 also serves cofactor nitric oxide synthase which produces from vascular endothelium, platelets, neutrophils, neurons.2 Upon oxidation quinonoid dihydrobiopterin (qBH2), regenerated by dihydropteridine reductase (NAD[P]H:6,7-dihydropteridine oxidoreductase, EC 1.6.99.7;DHPR) using NADH cofactor.3 DHPR ubiquitous.4 Their parallel distribution some organs blood cells apparently do not synthesize catecholamine neurotransmitters and/or oxide, implies that may involve other physiological functions.