Neopterin as an endogenous antioxidant
作者： Shuji Kojima , Takeshi Icho , Yoshio Kajiwara , Kazuhiko Kubota
DOI: 10.1016/0014-5793(92)80610-S
关键词:
摘要: The in vitro potency of neopterin (NP) as an antioxidant and its vivo activity to suppress alloxan-induced diabetes were investigated. reduced form neopterin, 5,6,7,8-tetrahydroneopterin (NPH-4), showed extremely high superoxide anion radical scavenging two assay systems, i.e. xanthine/xanthine oxidase- macrophage/phorbol myrislate acetate (PMA)-reaction systems. NPH-4 also inhibited the oxidation linoleic acid about effectively uric acid. Furthermore, NP suppressed mouse diabetes. These results suggest that pteridines play important role endogenous antioxidant.
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