A metric map of humans: 23,500 loci in 850 bands

摘要: High-resolution maps integrated with the enhanced location data base software (ldb+) give improved estimates of genetic parameters and reveal characteristics cytogenetic bands. Chiasma interference is intermediate between Kosambi Carter–Falconer levels, as in Drosophila mouse. The autosomal map 2832 4348 centimorgans males females, respectively. Telomeric T-bands are strikingly associated male recombination gene density. Position centromeric heterochromatin have large effects, but nontelomeric R-bands not significantly different from G-bands. Several possible reasons discussed. These regularities validate maps, despite their high resolution inevitable local errors. No other approach has been demonstrated to integrate such a number loci, which increasing at about 45% per year. they constructed available through Internet (http://cedar.genetics.soton.ac.uk/public_html). Successive versions this may also be accessed on CD-ROM.