THE ENDOTHELIAL L-ARGININE/NITRIC OXIDE PATHWAY AND THE RENAL CIRCULATION

摘要: Endothelial cells contain an enzyme(s) which produces nitric oxide from L-arginine in response to a variety of mechanical stimuli as well autacoids and local circulating hormones. Nitric is potent vasodilator inhibitor platelet function; it exerts its effects via activation soluble guanylate cyclase subsequent formation cyclic 3′–5′-guanosine monophosphate. In the kidney, endothelial pathway associated with increases renal blood flow, diuresis natriuresis, while glomerular filtration rate remains constant. The activity impaired hypertension during chronic therapy cyclosporine A. addition, diabetes atherosclerosis impair this pathway. Thus, plays important role regulation flow. Alterations may play pathophysiology disease.