Alkylation of Purine Bases by Carbon-Centered Radicals

摘要: Mono- and di-substituted hydrazines are found ubiquitously (1, 2). They present in the environment since they used as herbicides, chemical intermediates, high energy fuels for rockets. plants such tobacco mushrooms. also medicine. All substituted tested carcinogenicity long-term animal studies have been to be positive (1). 1, 2-dimethylhydrazine (DMH) is a well known carcinogen that induces tumors specifically colon of rodents (3). Since DMH-induced lesions characteristics remarkably similar those human cancer, this widely model study cancer. The ethyl derivative DMH, 2-diethylhydrazine (DEH), carcinogen. DEH produces cancer thymus, liver, brain (4). mechanism(s) by which these di-alkyl induce not known. Kang et al. (5) shown rats metabolism DMH methyl radicals (·CH3) (·CH2CH3), respectively. Therefore, investigation was conducted explore nature interaction(s) between alkyl biomolecules using CH3 RNA models.