Pharmacokinetics and Pharmacodynamics

摘要: The theoretical background provided by L. E. Mather and G. K. Gourlay (this volume) indicated that the TTS fentanyl systems can provide a zero order input rate for at least 24 h would mimic constant intravenous infusion. In fact, delivery of 100 µg/h have been shown to similar serum concentrations steady state infusion an equivalent [6]. currently available methods treating postoperative pain also reviewed (Part 2). continuous number opioids including morphine [18], pethidine [19] [14] has more reliable relief than obtained from conventional intramuscular opioid regimens. However, there is five-fold range interpatient variability in minimum effective blood concentration (MEC) required effectively control [2, 5, 8, 20]. Therefore, are two possible approaches clinical implementation infusions pain. Firstly, physician could use rates which will steady-state towards higher end MECs, thereby providing acceptable majority patients. disadvantage approach still be inadequate some patients while being excessive significant proportion patients, probably causing unwanted unpleasant side effects.The second attempt individualize each patient maximize but minimize effects.