Morphine: controlled trial of different methods of administration for postoperative pain relief.

摘要: Forty-five patients who had undergone major operations were given a slow intravenous injection of morphine sulphate (1 mg/ml saline) until their pain was relieved and then randomly divided into three equal groups to receive different regimens over the next 72 hours. Patients in group A received 3.5 times pain-relieving dose (28-63 mg, mean 36 mg) by continuous infusion; those B (90-160 110 intramuscularly, four-hourly for first 24 hours, six-hourly eight 20 hours later; C (80-280 140 intramuscularly as required. Pain assessed on linear analogue scale vital capacity peak expiratory flow rate measured 12-hourly. The score significantly lower respiratory function better than C. Only one patient (in A) required extra morphine. Thus administered infusion is superior other regimens, giving relief at dosage.