Long Noncoding RNA EWSAT1 Promotes Osteosarcoma Cell Growth and Metastasis Through Suppression of MEG3 Expression.
作者： Lishan Sun , Cheng Yang , Juan Xu , Yanhong Feng , Liguo Wang
关键词:
摘要: Osteosarcoma (OS) is the most common primary bone tumor in children and adolescents. Long noncoding RNAs (lncRNAs) are a class of transcriptional products genome without protein-coding potential. Recently, lncRNA Ewing sarcoma-associated transcript 1 (EWSAT1) was functionally identified sarcoma, highly aggressive pediatric tumor. However, whether EWSAT1 plays role OS remains unclear. In present study, gain- loss-of-function assays demonstrated that enhanced cell proliferation, migration, invasion. Further mechanistic studies found positively regulated MEG3 expression level. Finally, we observed facilitates growth metastasis through regulation MEG3, suggesting EWSAT1-MEG3 axis might be promising target for treatment.
sci-hub.se 参考文章(23)
C. WANG, G. YAN, Y. ZHANG, X. JIA, P. BU, Long non-coding RNA MEG3 suppresses migration and invasion of thyroid carcinoma by targeting of Rac1. Neoplasma. ,vol. 62, pp. 541- 549 ,(2015) , 10.4149/NEO_2015_065
Wendong Ruan, Pei Wang, Shiqing Feng, Yuan Xue, Yulin Li, Long non-coding RNA small nucleolar RNA host gene 12 (SNHG12) promotes cell proliferation and migration by upregulating angiomotin gene expression in human osteosarcoma cells. Tumor Biology. ,vol. 37, pp. 4065- 4073 ,(2016) , 10.1007/S13277-015-4256-7
Tanmoy Mondal, Santhilal Subhash, Roshan Vaid, Stefan Enroth, Sireesha Uday, Björn Reinius, Sanhita Mitra, Arif Mohammed, Alva Rani James, Emily Hoberg, Aristidis Moustakas, Ulf Gyllensten, Steven J.M. Jones, Claes M Gustafsson, Andrew H Sims, Fredrik Westerlund, Eduardo Gorab, Chandrasekhar Kanduri, MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA–DNA triplex structures Nature Communications. ,vol. 6, pp. 7743- 7743 ,(2015) , 10.1038/NCOMMS8743
Xiaoying Zhou, Guoping Ji, Xiquan Ke, Huiyuan Gu, Wujuan Jin, Guoxin Zhang, MiR-141 Inhibits Gastric Cancer Proliferation by Interacting with Long Noncoding RNA MEG3 and Down-Regulating E2F3 Expression Digestive Diseases and Sciences. ,vol. 60, pp. 3271- 3282 ,(2015) , 10.1007/S10620-015-3782-X
R. Qin, Z. Chen, Y. Ding, J. Hao, J. Hu, F. Guo, Long non-coding RNA MEG3 inhibits the proliferation of cervical carcinoma cells through the induction of cell cycle arrest and apoptosis. Neoplasma. ,vol. 60, pp. 486- 492 ,(2013) , 10.4149/NEO_2013_063
Michelle Marques Howarth, David Simpson, Siu P Ngok, Bethsaida Nieves, Ron Chen, Zurab Siprashvili, Dedeepya Vaka, Marcus R Breese, Brian D Crompton, Gabriela Alexe, Doug S Hawkins, Damon Jacobson, Alayne L Brunner, Robert West, Jaume Mora, Kimberly Stegmaier, Paul Khavari, E Alejandro Sweet-Cordero, None, Long noncoding RNA EWSAT1-mediated gene repression facilitates Ewing sarcoma oncogenesis Journal of Clinical Investigation. ,vol. 124, pp. 5275- 5290 ,(2014) , 10.1172/JCI72124
Kai-hua Lu, Wei Li, Xiang-hua Liu, Ming Sun, Mei-ling Zhang, Wei-qin Wu, Wei-ping Xie, Ya-yi Hou, Long non-coding RNA MEG3 inhibits NSCLC cells proliferation and induces apoptosis by affecting p53 expression BMC Cancer. ,vol. 13, pp. 461- 461 ,(2013) , 10.1186/1471-2407-13-461
Yanying Wang, Lei He, Ying Du, Pingping Zhu, Guanling Huang, Jianjun Luo, Xinlong Yan, Buqing Ye, Chong Li, Pengyan Xia, Geng Zhang, Yong Tian, Runsheng Chen, Zusen Fan, The Long Noncoding RNA lncTCF7 Promotes Self-Renewal of Human Liver Cancer Stem Cells through Activation of Wnt Signaling Cell Stem Cell. ,vol. 16, pp. 413- 425 ,(2015) , 10.1016/J.STEM.2015.03.003
Dan Xu, Sheng-xian Yuan, Nan Zhu, Wei-ping Zhou, Guang-shun Yang, Yu-zhao Wang, Jing-li Shang, Chun-fang Gao, Feng-rui Zhang, Fang Wang, Shu-han Sun, Fu Yang, Ling Zhang, Xi-song Huo, Ji-hang Yuan, Long noncoding RNA high expression in hepatocellular carcinoma facilitates tumor growth through enhancer of zeste homolog 2 in humans. Hepatology. ,vol. 54, pp. 1679- 1689 ,(2011) , 10.1002/HEP.24563
Xiaowen Hu, Yi Feng, Dongmei Zhang, Sihai D. Zhao, Zhongyi Hu, Joel Greshock, Youyou Zhang, Lu Yang, Xiaomin Zhong, Li-Ping Wang, Stephanie Jean, Chunsheng Li, Qihong Huang, Dionyssios Katsaros, Kathleen T. Montone, Janos L. Tanyi, Yiling Lu, Jeff Boyd, Katherine L. Nathanson, Hongzhe Li, Gordon B. Mills, Lin Zhang, A Functional Genomic Approach Identifies FAL1 as an Oncogenic Long Noncoding RNA that Associates with BMI1 and Represses p21 Expression in Cancer Cancer Cell. ,vol. 26, pp. 344- 357 ,(2014) , 10.1016/J.CCR.2014.07.009