Pharmacokinetics of Vindesine and Vincristine in Humans

摘要: Vindesine, a new Phase 1 Vinca alkaloid congener, exhibited serum pharmacokinetic behavior in humans compatible with three-compartment, open mammillary model. The kinetic parameters included: t 1/2 α = 3.24 ± 1.14 min, β 99.0 44.5 γ 1213 493 V c ( α) 4.81 2.12 liters, 58.2 50.5 598 294 liters. Vincristine, studied only for the first 4 hr, behaved like two-compartment system, values of 3.37 0.72 155 18 4.53 0.49 and 57.3 21.1 Urine excretion data demonstrated that most drug elimination occurred within 24 hr amounted to 13.2 5.9% vindesine 9.5 5.1% vincristine.