Biological and Biomedical Aspects of Metal Phenolates

摘要: The phenol functionality is involved in diverse biological processes and functions, serving as a proton donor metal-binding ligand. It commonly found many biochemicals (such siderophores the amino acids tyrosine tryptophan), pharmaceuticals (including antibiotics, metal-chelating agents, diagnostic agents), natural products polyphenols, flavonoids, salicylic acid). In association with other functional groups, moiety forms various types of sites structures for example, iron binding transport, enzymes oxygenation substrates, biotransformation aromatic compounds. Many environmentally hazardous compounds such bisphenol A, PCB, DDT can be degraded by tyrosinate(phenolate)-containing metalloenzymes from microorganisms, which provides clue bioremediation these toxic substances. Moreover, phenol-containing wet-adhesive byssal proteins some clams mussels has stimulated further development adhesive materials medical applications; study transferrin nanoparticles affords better understanding protein–mineral interfacial interactions. addition to naturally occurring metal-phenolate centers, there are metal complexes derivatives that exhibit catalytic activities serve structural and/or model systems tyrosinate-containing metalloproteins. Keywords: phenol; catechol; polyphenol; metalloenzyme; metalloproteins; metallodrugs; metallopharmaceutical; environment; materials