Antiviral protection by CD8+ versus CD4+ T cells. CD8+ T cells correlating with cytotoxic activity in vitro are more efficient in antivaccinia virus protection than CD4-dependent IL.

摘要: T cell-mediated protection against a recombinant vaccinia virus was evaluated in mice with respect to the relative contributions of CTL vs that cell-dependent IL and CD4+ cells. H-2b primed wildtype vesicular stomatitis serotype Indiana (VSV-IND wt) mount an vitro measurable cytotoxic response nucleoprotein (NP) VSV-IND are protected challenge infection vaccinia-VSV expressing NP (vacc-IND-NP). Their protective mechanism highly susceptible vivo depletion CD8+ cells, but resistant or treatment anti-IFN-gamma anti-TNF-alpha. Surprisingly, also VSV-CTL nonresponder H-2k were challenging vacc-IND-NP when wt. In contrast responder mice, this cell anti-TNF-alpha treatment, depletion. Antibodies not responsible because they failed transfer protection; cells conferred significant protection. almost equally well dose 10(3) pfu inoculated intracerebrally. However, after intracerebral 5 x 10(6) vacc-IND-NP, died, whereas eliminated by day 5. These results collectively show may mediate antiviral protection, their efficiency is relatively weak compared CD8-mediated correlating activity vitro.