Prefrontal cortex and reversion of atropine-induced disruption of the degraded contingency effect by antipsychotic agents and N -desmethylclozapine in rats

摘要: Interactive context processing is a cognitive ability that altered in psychotic states, including schizophrenia. This deficit has been linked to prefrontal cortical dysfunction humans. The degraded contingency effect (DCE) simple form of interactive by which contextual information interferes with target conditioned stimulus for control over responding. We have previously shown the DCE was disrupted muscarinic receptor antagonist atropine and this disruption specifically restored cholinergic drugs displaying an antipsychotic-like profile, such as physostigmine or xanomeline. selectively associated increase Fos immunoreactivity medial cortex (mPFC), not observed presence atropine. Here, we set out test actions typical, atypical potential antipsychotics on atropine-induced related mPFC Fos-immunoreactivity profile. Low doses haloperidol, olanzapine, clozapine N-desmethylclozapine reversed DCE, but different dose-dependent curves (linear shapes haloperidol N-desmethylclozapine, inverted U olanzapine clozapine). level within paralleled pharmacological profile drugs. Compared contingent groups, increased only DCE. These results suggest processing, hallmark might originate from mere fundamental associative processes. result blockade PFC.