Modeling of in vitro drug activity and prediction of clinical outcome in acute myeloid leukemia.
作者： Angelica Quartino , Mats O. Karlsson , Agneta Freijs , Niclas Jonsson , Peter Nygren
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摘要: The objectives of this study were to develop a population pharmacodynamic model describing the in vitro drug sensitivity tumor cells and relate parameters clinical outcome. Cell samples from 179 patients with acute myelocytic leukemia exposed cytosine arabinoside daunorubicin, cytotoxicity was analyzed using fluorometric microculture assay. A sigmoid E(max)-model for daunorubicin an described data. predicted potency (EC(50)) adequately 1 concentration measurement. logistic regression on individual 46 treated plus regimen showed that probability complete response significantly (P < .05) related product E(max)/EC(50) ratio two drugs. findings demonstrate value modeling data significant relationship between
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