Implication of IRF4 Aberrant Gene Expression in the Acute Leukemias of Childhood

摘要: The most frequent targets of genetic alterations in human leukemias are transcription factor genes with essential functions normal blood cell development. Interferon Regulatory Factor 4 (IRF4) gene encodes a important for key developmental stages hematopoiesis, known oncogenic implications multiple myeloma, adult and lymphomas. Very few studies have reported an association IRF4 childhood malignancy, whereas high transcript levels been observed the more mature immunophenotype ALL. Our aim was to investigate expression diagnostic samples pediatric compare them those healthy controls, order determine aberrant whether it extends leukemic subtypes other than relatively ALL subpopulation. Quantitative real-time RT-PCR methodology used 58 children acute leukemias, lines 20 children. We show that is implicated variety subtypes; higher appear immature B-common subtype T-cell B-cell highest appearing AML group. Interestingly, we leukemia, irrespective or maturation stage, characterised by minimum approximately twice amount encountered A statistically significant correlation also appeared exist between relapse. results ectopic follows reverse pattern what development there might be dose-dependency leukemia aberrantly expressed IRF4, characteristic could explored therapeutically. It suggested as additional prognostic marker relapse at diagnosis.