Changes in gene expression induced by aromatic amine drugs: Testing the danger hypothesis

摘要: Virtually all drugs that contain a primary aromatic amine are associated with high incidence of idiosyncratic drug reactions (IDRs), suggesting this functional group has biological effects may be used as biomarkers to predict IDR risk. Most IDRs exhibit evidence immune involvement and the ability amines form reactive metabolites redox cycle responsible for initiation an response through induction cell stress, postulated by Danger Hypothesis. If true, danger signals could A previous attempt test Hypothesis found sulfamethoxazole (SMX), only tested, was also not increase stress genes in mice. To ensure these observations were species-specific, determine risk common amines, rats treated SMX two other drugs, dapsone (DDS) aminoglutethimide (AMG), hepatic gene expr...