Intrahepatic immunity: a tale of two sites?

摘要: The intrahepatic immune environment is associated with the induction of tolerance, yet maintains capacity to sustain effective responses against pathogens. mechanisms underlying this dichotomy are unclear. Recent data indicate that activation naive CD8 + T cells occurs within liver. However, in contrast efficient primary observed lymph nodes, pathway relatively ineffective, leading reduced T-cell cytotoxicity and survival. Thus, outcome might be determined by whether tolerogenic liver, or immunity induced initial antigen encounter nodes. These findings support a novel model hepatic–immune interactions, implications for our understanding paradoxical nature liver immunobiology.