Specific, functional effector/memory CD8+ T cells are found in the liver post-vaccination.

摘要: Abstract Background : The liver efficiently eliminates activated CD8 + T blasts. It is unknown if vaccine-primed blasts migrate to and establish functional cell immunity in the post-immunization. Aims We tested, populations can be detected post-vaccination. Methods Murine cells with different epitope/restriction specificities were primed by intramuscular injection of protein- or DNA-based vaccines. kinetics appearance liver, as well surface phenotype competence intrahepatic, specific was tested. Results High numbers appear after vaccination that are (CD69 CD44 ), express effector functions (CD27 lo /CD28 phenotype, interferon γ secretion, cytolytic reactivity), but show no evidence apoptosis (annexin V − , B220 similar numbers/kinetics primed, congenic lpr/lpr mice). Specific from adoptively transferred into a naive, syngeneic host successfully reconstitute immunity. Conclusions Specific, functionally competent effector/memory established for months