Low CD4+ T Cell Nadir Is an Independent Predictor of Lower HIV-Specific Immune Responses in Chronically HIV-1–Infected Subjects Receiving Highly Active Antiretroviral Therapy
作者： M. Atif Siddique , Kelly E. Hartman , Ella Dragileva , Marla Dondero , Tebeb Gebretsadik
DOI: 10.1086/505913
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摘要: The influence of CD4 + T cell nadirs on human immunodeficiency virus (HIV)-specific immune responses in subjects with apparently normal counts is not known. We evaluated the frequency HIV-1-specific a cohort patients complete viral suppression (HIV-1 RNA load, <50 copies/mL) who were receiving highly active antiretroviral therapy and had wide range nadirs. found positive associations between magnitude HIV-specific CD8 (P =.02) helper =.04). These data show nadir to be an independent predictor HIV-1-infected optimal viremia.
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