Homologous blood transfusion as a risk factor for postoperative infection after coronary artery bypass graft operations.
作者： Paul J. Murphy , Cliff Connery , George L. Hicks , Neil Blumberg
DOI: 10.1016/S0022-5223(19)34696-3
关键词:
摘要: Homologous transfusions are immunosuppressive and associated with a higher risk of postoperative infection. In this retrospective analysis, we studied 238 consecutive patients who underwent first-time coronary operations by single surgeon in 1988 to 1989 collected clinical laboratory data relevant infections including pulmonary, urinary, wound sites. Culture-proved occurred 16 the (6.7%), only 3 (1.3%) being deep sternal infections. Seven (44%) were away from sites, suggesting that nonsurgical variables contributed at least some Factors significantly an increased infection univariate analysis included female sex, diabetes mellitus, transfusion dose. Infections 3.9% receiving up 2 units red cells whole blood, 6.9% 5 units, 22% those 6 or more. Multiple linear logistic regression showed dose was most significant predictor infection, days fever, antibiotic therapy, length hospital stay. is (in dose-dependent fashion) threefold eightfold undergoing artery operations. This may be due transfusion-induced immunosuppression patient.
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