Expanding role of the medical oncologist in the management of head and neck cancer.

摘要: The multidisciplinary approach to treating squamous cell carcinoma of the head and neck is complex evolving. This article aims review some recent developments in neck, particular expanding role chemotherapy its management. Surgery radiotherapy have remained mainstay therapy. Chemotherapy increasingly being incorporated into treatment neck. Previously, following surgery was standard locoregionally advanced resectable disease. Data from randomized trials confirmed benefits concurrent chemoradiotherapy adjuvant setting. Chemoradiotherapy also recommended for unresectable Induction has been useful disease where organ preservation desirable, but this inferior goal larynx preservation, while leading similar survival when compared with concomitant chemoradiotherapy. There evidence that taxanes added induction cisplatin fluorouracil result improved outcomes. Novel targeted agents, such as epidermal growth factor receptor antagonists, are showing promise patients both recurrent/metastatic