Advanced nanostructured medical device combining mesenchymal cells and VEGF nanoparticles for enhanced engineered tissue vascularization
作者： Quentin Wagner , Damien Offner , Ysia Idoux-Gillet , Imran Saleem , Satyanarayana Somavarapu
关键词:
摘要: AIM: Success of functional vascularized tissue repair depends on vascular support system supply and still remains challenging. Our objective was to develop a nanoactive implant enhancing endothelial cell activity, particularly for bone engineering in the regenerative medicine field. MATERIALS & METHODS: We developed new strategy tridimensional based cell-dependent sustained release VEGF nanoparticles. These nanoparticles were homogeneously distributed within nanoreservoirs onto porous scaffold, with quicker reorganization cells. Moreover, activity this active smart cells also modulated by addition osteoblastic RESULTS CONCLUSION: This sophisticated should potentiate efficiency current therapeutic implants repair, avoiding need substitutes.
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