Nanoparticulate Systems for Growth Factor Delivery

摘要: The field of nanotechnology, which aims to control and utilize matter generally in 1-100 nm range, has been at the forefront pharmaceutical development. Nanoparticulate delivery systems, with their potential drug release profiles, prolonging presence drugs circulation, target a specific site, hold tremendous promise as strategies for therapeutics. Growth factors are endogenous polypeptides that initiate intracellular signals regulate cellular activities, such proliferation, migration differentiation. With improved understanding roles physiopathology expansion availability through recombinant technologies, growth becoming leading therapeutic candidates tissue engineering approaches. However, outcome factor therapeutics largely depends on mode due rapid degradation vivo, non-specific distribution after systemic administration. In order overcome these impediments, nanoparticulate systems being harnessed spatiotemporal controlled factors. This review presents recent advances some disadvantages various designed effective intact delivery. applications delivered by reviewed, especially bone, skin nerve regeneration well angiogenesis. Finally, future challenges directions presented addition current limitations.