Metabotropic Glutamate Receptor-1 as a Novel Target for the Antiangiogenic Treatment of Breast Cancer

摘要: Metabotropic glutamate receptors (mGluRs) are normally expressed in the central nervous system, where they mediate neuronal excitability and neurotransmitter release. Certain cancers, including melanoma gliomas, express various mGluR subtypes that have been implicated as playing a role disease progression. Recently, we detected metabotropic receptor-1 (gene: GRM1; protein: mGluR1) breast cancer found it plays regulation of cell proliferation tumor growth. In addition to cells, brain endothelial cells mGluR1. light these studies, because angiogenesis is both prognostic indicator correlating with poorer prognosis potential therapeutic target, explored for mGluR1 mediating (EC) tumor-induced angiogenesis. GRM1 were types human ECs and, using mGluR1-specific inhibitors or shRNA silencing, demonstrated EC growth Matrigel tube formation dependent on signaling. addition, loss activity leads reduced murine sponge implant model well model. These results suggest pro-angiogenic factor mediator They also new molecular target anti-angiogenic therapy cancer.