Potentiation of the antitumor effect of ionizing radiation by brief concomitant exposures to angiostatin.

作者: Ralph R. Weichselbaum , Helena J. Mauceri , Donald W. Kufe , Rabih M. Salloum , Gerald A. Soff

DOI:

关键词: ConcomitantMedicineAngiostatinIonizing radiationPathologyRatónLewis lung carcinomaInternal medicineNeovascularizationEndocrinologyCarcinomaAngiogenesis

摘要: Abstract Angiostatin, a proteolytic fragment of plasminogen, inhibits the growth primary and metastatic tumors by suppressing angiogenesis. When used in combination with ionizing radiation (IR), angiostatin demonstrates potent antitumor synergism, largely caused inhibition tumor microvasculature. We report here temporal interaction IR Lewis lung carcinoma (LLC) growing hind limbs syngeneic mice. Tumors an initial mean volume 510 ± 151 mm 3 were treated alone (20 Gy × 2 doses on days 0 1), (25 mg/kg/day divided twice daily) through 13, or two as follows: ( ) plus (days 13); b 1); c followed beginning day after completion given daily thereafter 13). By 14, untreated control mice had grown to 6110 582 , whereas with: alone, 2854 338 P 3666 453 longer-course angiostatin, reached 2022 282 = 0.036 compared alone); 2677 469 > 0.05 short-course 1032 78

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