Multiple female reproductive failures in cyclooxygenase 2-deficient mice.

摘要: Cyclooxygenase (COX) is the rate-limiting enzyme in synthesis of prostaglandins (PGs) and exists two isoforms, COX-1 COX-2. In spite long-standing speculation, definitive roles PGs various events early pregnancy remain elusive. We demonstrate herein that targeted disruption COX-2, but not COX-1, mice produces multiple failures female reproductive processes include ovulation, fertilization, implantation, decidualization. Using approaches, we conclude these defects are direct result target organ-specific COX-2 deficiency pituitary gonadotropins or ovarian steroid hormones, reduced responsiveness organs to their respective hormones.