Treatment of knee osteoarthritis: relationship of clinical features of joint inflammation to the response to a nonsteroidal antiinflammatory drug or pure analgesic.

摘要: Our randomized double blinded comparison of acetaminophen versus analgesic and antiinflammatory doses ibuprofen in the treatment 182 subjects with knee osteoarthritis (OA) systematically evaluated soft tissue tenderness joint swelling. Improvement these signs inflammation was associated lessening disability (p = 0.02), reduction rest pain 0.07), but not drug regimen. Thus, swelling, presumptive evidence synovitis, may be a priori indications for use an drug, or predict greater responsiveness to than pure analgesic, symptomatic patients OA.