Glial Progenitors as Targets for Transformation in Glioma
作者： Shirin Ilkhanizadeh , Jasmine Lau , Miller Huang , Daniel J. Foster , Robyn Wong
DOI: 10.1016/B978-0-12-800249-0.00001-9
关键词:
摘要: Glioma is the most common primary malignant brain tumor and arises throughout central nervous system. Recent focus on stem-like glioma cells has implicated neural stem (NSCs), a minor precursor population restricted to germinal zones, as potential source of gliomas. In this review, we relationship between oligodendrocyte progenitor (OPCs), largest cycling glial progenitors in postnatal brain, gliomagenesis. OPCs can give rise gliomas, with signaling pathways associated NSCs also playing key roles during OPC lineage development. Gliomas undergo switch from progenitor- phenotype after therapy, consistent an OPC-origin even for Future in-depth studies biology may shed light etiology OPC-derived gliomas reveal new therapeutic avenues.
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