Mycophenolate mofetil prevents salt-sensitive hypertension resulting from angiotensin II exposure.

摘要: Mycophenolate mofetil prevents salt-sensitive hypertension resulting from angiotensin II exposure. Background Interstitial mononuclear cell infiltration is a feature of experimental models (SSHTN). Since several products these cells are capable modifying local vascular reactivity and sodium reabsorption, we investigated whether mycophenolate (MMF), drug known to inhibit proliferation immune cells, would modify the SSHTN induced by (Ang II) infusion. Methods Sprague-Dawley rats received Ang for two weeks using subcutaneous minipumps. A high-sodium (4% NaCl) diet was started on third week maintained until eighth week. MMF (30 mg/kg, N = 15), an immunosuppressive drug, or vehicle ( 15) given daily gastric gavage during initial three weeks. Sham-operated 9) were used as controls. Body weight, blood pressure (tail-cuff plethysmography), serum creatinine determined weekly. Urinary malondialdehyde (MDA) excretion, renal histology, immunohistology, including presence superoxide-producing analyzed at end infusion eight Results treatment did not exogenous infusion, but prevented subsequent SSHTN. Tubulointerstitial injury significantly reduced treatment, proliferative activity, T-cell activation (interleukin-2 receptor expression), urinary MDA excretion. II-producing present in tubulointerstitium with (60 ± 30 II-positive cells/mm 2 8 weeks) thirds MMF-treated group. Forty percent lymphocytes infiltrating stained positive II. The expression receptors kidney unmodified. Conclusions associated that produce reduces features development