Studies on erythropoietin. I. Demonstration of erythropoietin in normal plasma.

摘要: 1. A modification of a technic wherein hypertransfused rats are used for the bioassay erythropoietin is described, and some kinetics iron incorporation following transfusion presented. 2. It was possible to detect activity in normal plasma demonstrate that animals whose erythropoiesis depressed below by hypertransfusion possesses less than plasma. 3. The variation response under standardized conditions sufficiently small predictable so within certain limits, quantitation possible. dose-response analysis presented. 4. Plasma from approximately 25 per cent found rendered acutely anemic blood loss.