The role of imported cases in the epidemiology of urban Plasmodium falciparum malaria in Quibdo, Colombia
作者： L. Osorio , J. Todd , R. Pearce , D. J. Bradley
DOI: 10.1111/J.1365-3156.2006.01791.X
关键词:
摘要: OBJECTIVE To assess the role of imported cases in local epidemiology malaria and population genetics Plasmodium falciparum an urban endemic area Colombia. METHOD A total 679 P. presenting city were interviewed, mapped, genotyped using msp1 msp2 molecular markers. RESULTS Among cases, 75% classified as harboured single-clone infections. The parasite had low genetic diversity with a preponderant haplotype (mean H = 0.36), even when microsatellite markers used (H 0.49), partly because small scale at which movement was studied. Nevertheless, indigenous potentially introduced identified. CONCLUSION Migration is confounder planning control this area. Longitudinal studies monitor autochthonous larger spatial scales would be necessary to study effect on transmission and, suitable markers, spread drug resistance.
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