Early detection and treatment of ovarian cancer: shifting from early stage to minimal volume of disease based on a new model of carcinogenesis

作者: Robert J. Kurman , Kala Visvanathan , Richard Roden , T.C. Wu , Ie-Ming Shih

DOI: 10.1016/J.AJOG.2008.01.005

关键词:

摘要: … and the adjacent mucinous cystadenoma and MBT share the same KRAS mutation, 14 indicating that these tumors have a common lineage and support the view that mucinous …

参考文章(53)
Estrid V.S Høgdall, Claus K Høgdall, Jan Blaakaer, Lise Christensen, Johannes E Bock, Jens Vuust, Eva Glud, Susanne K Kjaer, K-ras alterations in Danish ovarian tumour patients. From the Danish "Malova" Ovarian Cancer study. Gynecologic Oncology. ,vol. 89, pp. 31- 36 ,(2003) , 10.1016/S0090-8258(03)00005-2
J M Rice, T Enomoto, M Inoue, C M Weghorst, O Tanizawa, K-ras activation occurs frequently in mucinous adenocarcinomas and rarely in other common epithelial tumors of the human ovary. American Journal of Pathology. ,vol. 139, pp. 777- 785 ,(1991)
Georgia Chenevix-Trench, Andrew Hitchcock, Eric J. Thomas, Sarah J. Morland, Ian G. Campbell, Richard H. Watson, Koshiro Obata, Frequent PTEN/MMAC mutations in endometrioid but not serous or mucinous epithelial ovarian tumors. Cancer Research. ,vol. 58, pp. 2095- 2097 ,(1998)
Paula M. Fishbaugh, Paula M. Fishbaugh, Michael G. Muto, Michael G. Muto, Ross S. Berkowitz, Samuel Chi-Ho Mok, Robert C. Knapp, Robert C. Knapp, William R. Welch, Debra A. Bell, Debra A. Bell, Sai-Wah Tsao, Mutation of K-ras Protooncogene in Human Ovarian Epithelial Tumors of Borderline Malignancy Cancer Research. ,vol. 53, pp. 1489- 1492 ,(1993)
J Milner, E A Medcalf, A C Cook, Tumor suppressor p53: analysis of wild-type and mutant p53 complexes. Molecular and Cellular Biology. ,vol. 11, pp. 12- 19 ,(1991) , 10.1128/MCB.11.1.12
Ie-Ming Shih, Robert J. Kurman, Ovarian Tumorigenesis : A Proposed Model Based on Morphological and Molecular Genetic Analysis American Journal of Pathology. ,vol. 164, pp. 1511- 1518 ,(2004) , 10.1016/S0002-9440(10)63708-X
J. Kupryjanczyk, A. D. Thor, R. Beauchamp, V. Merritt, S. M. Edgerton, D. A. Bell, D. W. Yandell, p53 gene mutations and protein accumulation in human ovarian cancer Proceedings of the National Academy of Sciences of the United States of America. ,vol. 90, pp. 4961- 4965 ,(1993) , 10.1073/PNAS.90.11.4961
Doris Mayr, Astrid Hirschmann, Udo Löhrs, Joachim Diebold, KRAS and BRAF mutations in ovarian tumors: A comprehensive study of invasive carcinomas, borderline tumors and extraovarian implants Gynecologic Oncology. ,vol. 103, pp. 883- 887 ,(2006) , 10.1016/J.YGYNO.2006.05.029
Tsuyoshi Okuda, Junko Otsuka, Akihiko Sekizawa, Hiroshi Saito, Reiko Makino, Miki Kushima, Antonio Farina, Yuzuru Kuwano, Takashi Okai, p53 mutations and overexpression affect prognosis of ovarian endometrioid cancer but not clear cell cancer Gynecologic Oncology. ,vol. 88, pp. 318- 325 ,(2003) , 10.1016/S0090-8258(02)00149-X