Correcting for cancer genome size and tumour cell content enables better estimation of copy number alterations from next-generation sequence data

作者: Arief Gusnanto , Henry M. Wood , Yudi Pawitan , Pamela Rabbitts , Stefano Berri

DOI: 10.1093/BIOINFORMATICS/BTR593

关键词:

摘要: … an M-vector of ploidy or copy number and ε is the error term. If the model fit (in terms of R 2 ) falls below a certain threshold, we ‘juggle’ the different copy numbers in P* to include values …

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