Novel nanocomposite biomaterials with controlled copper/calcium release capability for bone tissue engineering multifunctional scaffolds
作者： J. P. Cattalini , A. Hoppe , F. Pishbin , J. Roether , A. R. Boccaccini
关键词:
摘要: This work aimed to develop novel composite biomaterials for bone tissue engineering (BTE) made of bioactive glass nanoparticles (Nbg) and alginate cross-linked with Cu2+ or Ca2+ (AlgNbgCu, AlgNbgCa, respectively). Two-dimensional scaffolds were prepared the nanocomposite characterized in terms morphology, mechanical strength, bioactivity, biodegradability, swelling capacity, release profile cross-linking cations angiogenic properties. It was found that both are released a controlled sustained manner no burst observed. Finally, vitro results indicated ions from able stimulate differentiation rat marrow-derived mesenchymal stem cells towards osteogenic lineage. In addition, typical endothelial cell property forming tubes Matrigel observed human umbilical vein when contact biomaterials, particularly AlgNbgCu, which indicates their Hence, Nbg developed potential applications preparation multifunctional BTE.
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