Natural Origin Materials for Bone Tissue Engineering – Properties, Processing, and Performance

作者: V.M. Correlo , J.M. Oliveira , J.F. Mano , N.M. Neves , R.L. Reis

DOI: 10.1016/B978-0-12-381422-7.10032-X

关键词: Blowing agentThermoplasticCompression moldingPorosityStarchMaterials scienceChitosanSpinningComposite materialExtrusion

摘要: This chapter focuses on properties, processing, and performance of natural origin materials employed for bone tissue engineering. One the is starch, a predominant energy-storing compound in many plants. Due to thermoplastic behavior starch-based blends composites, it possible produce 3D porous scaffolds using traditional melt-based technologies, such as compression molding combined with particulate leaching, injection or extrusion blowing agents. The two types produced by this method exhibit typical fiber-mesh structure, fiber diameter approximately 180 μm SPCL 210 SPLA, highly interconnected pores porosity 75%. Another material chitosan, homopolymer β (1→4)-linked N -acetyl-D-glucosamine residues. A very interesting property chitosan that can be transformed into structures high degree interconnectivity various technologies; example, lyophilizing frozen solution powder dissolved acetic acid. obtained have porosities ∼ 80% median pore diameters 68 μm. mean controlled within range 1-250 varying freezing conditions. Wet spinning one most used methods fibers has been prepare meshes. an average size 100-500 μm, which ideal bone-related applications.

参考文章(192)
Susan Liao, Casey K. Chan, S. Ramakrishna, Stem cells and biomimetic materials strategies for tissue engineering Materials Science and Engineering: C. ,vol. 28, pp. 1189- 1202 ,(2008) , 10.1016/J.MSEC.2008.08.015
G Torun Köse, FEZA Korkusuz, PETEK Korkusuz, N Purali, AYKUT Özkul, V Hasırcı, None, Bone generation on PHBV matrices: an in vitro study Biomaterials. ,vol. 24, pp. 4999- 5007 ,(2003) , 10.1016/S0142-9612(03)00417-4
Feng Lin, Yucheng Li, Jun Jin, Yurong Cai, Kemin Wei, Juming Yao, Deposition behavior and properties of silk fibroin scaffolds soaked in simulated body fluid Materials Chemistry and Physics. ,vol. 111, pp. 92- 97 ,(2008) , 10.1016/J.MATCHEMPHYS.2008.03.019
Kjell M. Vårum, Mildrid M. Myhr, Ragnhild J.N. Hjerde, Olav Smidsrød, In vitro degradation rates of partially N-acetylated chitosans in human serum. Carbohydrate Research. ,vol. 299, pp. 99- 101 ,(1997) , 10.1016/S0008-6215(96)00332-1
Jorge Laine, Mary Labady, Alberto Albornoz, Simon Yunes, Porosities and pore sizes in coralline calcium carbonate Materials Characterization. ,vol. 59, pp. 1522- 1525 ,(2008) , 10.1016/J.MATCHAR.2007.12.002
I. Manjubala, Igor Ponomarev, Ingo Wilke, Klaus D. Jandt, Growth of Osteoblast-Like Cells on Biomimetic Apatite-Coated Chitosan Scaffolds Journal of Biomedical Materials Research Part B. ,vol. 84, pp. 7- 16 ,(2008) , 10.1002/JBM.B.30838
Alberto Di Martino, Michael Sittinger, Makarand V. Risbud, Chitosan: a versatile biopolymer for orthopaedic tissue-engineering. Biomaterials. ,vol. 26, pp. 5983- 5990 ,(2005) , 10.1016/J.BIOMATERIALS.2005.03.016
Lorenz Meinel, Vassilis Karageorgiou, Robert Fajardo, Brian Snyder, Vivek Shinde-Patil, Ludwig Zichner, David Kaplan, Robert Langer, Gordana Vunjak-Novakovic, Bone tissue engineering using human mesenchymal stem cells: Effects of scaffold material and medium flow Annals of Biomedical Engineering. ,vol. 32, pp. 112- 122 ,(2004) , 10.1023/B:ABME.0000007796.48329.B4
Yael Levi-Kalisman, Giuseppe Falini, Lia Addadi, Steve Weiner, Structure of the nacreous organic matrix of a bivalve mollusk shell examined in the hydrated state using cryo-TEM. Journal of Structural Biology. ,vol. 135, pp. 8- 17 ,(2001) , 10.1006/JSBI.2001.4372
Claire M. Tierney, Matthew G. Haugh, Jakob Liedl, Fergal Mulcahy, Brian Hayes, Fergal J. O’Brien, The effects of collagen concentration and crosslink density on the biological, structural and mechanical properties of collagen-GAG scaffolds for bone tissue engineering. Journal of The Mechanical Behavior of Biomedical Materials. ,vol. 2, pp. 202- 209 ,(2009) , 10.1016/J.JMBBM.2008.08.007