Dual nanofiber scaffolds composed of polyurethane- gelatin /nylon 6- gelatin for bone tissue engineering
作者： Mustafa Ghazali Ali , Hamouda M. Mousa , Fanny Blaudez , M.S. Abd El-sadek , M.A. Mohamed
DOI: 10.1016/J.COLSURFA.2020.124817
关键词:
摘要: The aim of the present study was to develop a fibrous scaffold with unique physiochemical, mechanical and biocompatible characteristics morphological structure similar native extracellular matrix (ECM). A dual non-woven ultrafine composed polyurethane (PU)/Nylon 6 (N6) hybrid polymers mixed natural gelatin (Gel) fabricated by syringe electrospinning technique. Pronounced composite fine fibers PU/N6 (148 ± 43 nm) (PU-Gel)/(N6-Gel) (161 79 an interconnected porosity were obtained. N6/Pu showed higher tensile strength modulus than PU-Gel/N6-Gel scaffold, whereas containing Gel induced largest elongation at breaking load. Biomimetic mineralization observed different time intervals formation bone apatite like layer on indicating good bioactivity. nanofibers had better wettability compared other scaffolds, supported high osteoblast cell proliferation. This suggests that scaffolds may have potential be applied in tissue engineering.
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