Evidence for a detrimental role of TLR8 in ischemic stroke

摘要: Toll-like receptors (TLRs) are transmembrane pattern-recognition that initiate signals in response to diverse pathogen-associated molecular patterns. Several groups have recently reported a role for TLR2 and TLR4 ischemic stroke-induced brain injury. However, relatively little is known about the of TLR8 stroke. Here we provide first evidence activation plays detrimental stroke outcome by promoting neuronal apoptosis T cell-mediated post-stroke inflammation. expressed cerebral cortical neurons, where its levels downstream signaling via JNK increased oxygen glucose deprivation (OGD). Treatment with agonist activated pro-apoptotic cell death during OGD. Furthermore, selective knockdown using siRNA protected SH-SY5Y cells following OGD, administration vivo mortality, neurological deficit infiltration Taken together, our findings indicate triggering inflammation death.