Efficacy of highly bioavailable zinc from fortified water: a randomized controlled trial in rural Beninese children.

摘要: Background: Zinc deficiency and contaminated water are major contributors to diarrhea in developing countries. Food fortification with zinc has not shown clear benefits, possibly because of low absorption from inhibitory food matrices. We used a novel pointof-use ultrafiltration device configured glass plates produce zinc-fortified, potable water. Objective: The objective was determine bioavailability filtered the efficacy zinc-fortified improving status. Design: In crossover balanced study, we measured fractional (FAZ) 18 healthy Swiss adults using stable isotopes compared it maize porridge. conducted 20-wk double-blind randomized controlled trial (RCT) 277 Beninese school children rural settings who were randomly assigned receive daily portion delivering 2.8 mg Zn (Zn+filter), nonfortified (Filter), or nonfiltered (Pump) local improved supply, acting as control group. main outcome plasma concentration (PZn), 3 groups by mixed-effects models. Secondary outcomes prevalence deficiency, prevalence, growth. Results: Geometric mean (2SD, +SD) FAZ 7-fold higher fortified (65.9%; 42.2, 102.4) than (9.1%; 6.0, 13.7; P