Alternative splicing in cancer: noise, functional, or systematic?

摘要: Pre-messenger RNA splicing is a fine-tuned process that generates multiple functional variants from individual genes. Various cell types and developmental stages regulate alternative patterns differently in their generation of specific gene functions. In cancers, significantly altered, understanding the underlying mechanisms cancer will shed new light onto biology. Cancer-specific transcript are promising biomarkers targets for diagnostic, prognostic, treatment purposes. this review, we explore how cannot simply be considered as noise or an innocent bystander, but actively regulated deregulated cancers. A special focus on aspects biology biochemistry cells, addressing differences between normal malignant cells. The systems only now applied to field research. We annotations some most intensely spliced classes, provide literature mining clustering reflects investigated few well-established cancer-specific splice events, such CD44 antigen, used illustrate potential behind exploration regulation. Accordingly, describe connection regulatory machinery (i.e., spliceosome its accessory proteins) global impact qualitative variation emerging use genomic technologies microarrays. These studies expected open entirely level genetic information currently still poorly understood.