Prediction of Reperfusion-Associated Hemorrhagic Transformation Using Dynamic Contrast-Enhanced Imaging in a Rat Stroke Model.

摘要: BACKGROUND AND PURPOSE Reperfusion-associated hemorrhagic transformation (HT) is an important complication of recanalization therapy. A method to identify stroke victims that may undergo HT will improve the patient selection and safety this treatment. In study, we determined relationship between timing reperfusion frequency severity HT, whether very early dynamic contrast-enhanced (DCE) imaging predicts occurrence reperfusion-associated in a model experimental stroke. METHODS Intraluminal suture occlusion middle cerebral artery was used produce transient ischemia male Sprague Dawley rats (n = 50). Reperfusion performed by withdrawal occluding filament after 3 10), 4 5 6 or 7 10) hours. Magnetic resonance studies were before using DCE, susceptibility-weighted imaging, diffusion-weighted T2- T1-weighted imaging. Follow-up magnetic histological at 24 RESULTS Hemorrhagic occurred hours injury 8 50 animals. The rate increased with prolonged ischemic duration. All animals exhibiting acute blood-brain barrier (BBB) perturbation subsequently developed Statistically significant differences BBB permeability parameters (P < 0.05) group non-HT detected DCE There also statistically area adjacent area. Among parameters, subcortex rK most sensitive specific predictor HT. CONCLUSIONS results suggest use quantitative measurements further prediction identification independent