Hemorrhagic transformation is related to the duration of occlusion and treatment with tissue plasminogen activator in a nonembolic stroke model.

摘要: Abstract The availability of reperfusion therapy for acute ischemic stroke patients has made the causes and significance hemorrhagic transformation an area intense interest controversy. Ninety-two male Wistar rats underwent transient middle cerebral artery occlusion (MCAO) between 1 6 h. Forty animals received 10 mg kg-1 recombinant tissue plasminogen activator (rtPA), infused over 20 min, starting 5 min before reperfusion. At 18-24 h, were sacrificed. presence (HT) on stained sections was recorded total lesion quantified using image analysis software. Seventeen (11 with HT) subjected to immunohistochemical detection endothelial barrier antigen (EBA), in three sections, eight different fields per section. Chi-squared logistic regression used assess contribution rtPA duration HT development. Nested, repeated measures analyses v...