Neuroendocrine tumours of the duodenum

摘要: Background and aims: Neuroendocrine tumours (NTs) of the duodenum are uncommon neoplasms. They represent a heterogeneous spectrum subtypes may be associated with von Recklinghausen’s disease type I (VRD) multiple endocrine neoplasia I. There few studies concerning biological characteristics adequate therapy these tumours. Patients methods: We report on retrospective analysis 12 patients NTs duodenum: six non-ampullary (naNTs) ampullary (aNTs). These were treated between January 1992 2001. Clinical histopathological features, follow-up evaluated retrospectively compared literature. Results: All located in first second portions duodenum. Three aNTs presented jaundice, four naNTs incidental findings. Two showed Zollinger-Ellison syndrome two VRD. Of naNTs, by local excision (two endoscopically, surgical resection), one Kausch-Whipple operation patient tumour was an finding Billroth II specimen. Four underwent procedure, ampullectomy (gangliocytic paraganglioma) palliative chemotherapy. The size less than 0.6 cm, whereas ranged from 1.5 cm to 4 cm. Tumour had no correlation depth invasion metastases. Metastases found none naNTs. Immunohistochemically cells expressed somatostatin 5 6 gastrin 1 gastrinomas. hospital mortality. died for reasons not related tumour. both gastrinomas curative. alive without disease. One treatment metastasising aNT is 66 months after diagnosis. Conclusion: Non-ampullary duodenal differ clinically, histologically immunohistochemically as well respect extent resection ampulla Vater.