Genetic polymorphisms in cytochrome P450 enzymes: effect on efficacy and tolerability of HMG-CoA reductase inhibitors.

作者: Andras Vermes , Istvan Vermes

DOI: 10.2165/00129784-200404040-00005

关键词:

摘要: … The aim of the present review is to investigate the interrelationship between the genetic polymorphism in cytochrome P450 (CYP) enzymes and the efficacy and tolerability of HMG-CoA …

参考文章(98)
R Gilad, Y Lampl, Rhabdomyolysis induced by simvastatin and ketoconazole treatment. Clinical Neuropharmacology. ,vol. 22, pp. 295- 297 ,(1999)
M Viganò, M B Regazzi, I Iacona, C Campana, G Perani, A Gavazzi, V Raddato, C Lesi, Altered disposition of pravastatin following concomitant drug therapy with cyclosporin A in transplant recipients. International Samuel L. Kountz symposium on renal disease and transplantation in blacks. ,vol. 25, pp. 2732- 2734 ,(1993)
Wilmarth J, Kamjoo P, Kobashigawa Ja, Brownfield E, Kawata N, Chuck C, Murphy Fl, Moriguchi Jd, Stevenson Lw, Leonard L, Low-dose lovastatin safely lowers cholesterol after cardiac transplantation. Circulation. ,vol. 82, ,(1990)
Regina W. Wang, Prasad H. Kari, Anthony Y.H. Lu, Paul E. Thomas, F.Peter Guengerich, Kamlesh P. Vyas, Biotransformation of lovastatin Archives of Biochemistry and Biophysics. ,vol. 290, pp. 355- 361 ,(1991) , 10.1016/0003-9861(91)90551-S
Kamlesh P. Vyas, Prasad H. Kari, Regina W. Wang, Anthony Y.H. Lu, Biotransformation of lovastatin--III. Effect of cimetidine and famotidine on in vitro metabolism of lovastatin by rat and human liver microsomes. Biochemical Pharmacology. ,vol. 39, pp. 67- 73 ,(1990) , 10.1016/0006-2952(90)90649-6
Rowland Yeo, Yeo, Wallis, Ramsay, Enhanced cholesterol reduction by simvastatin in diltiazem-treated patients British Journal of Clinical Pharmacology. ,vol. 48, pp. 610- 615 ,(1999) , 10.1046/J.1365-2125.1999.00066.X
Yasuko Kureishi, Zhengyu Luo, Ichiro Shiojima, Ann Bialik, David Fulton, David J. Lefer, William C. Sessa, Kenneth Walsh, The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nature Medicine. ,vol. 6, pp. 1004- 1010 ,(2000) , 10.1038/79510
C Sachse, S Bauer, J Brockmöller, I Roots, Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences. American Journal of Human Genetics. ,vol. 60, pp. 284- 295 ,(1997)
K. T. Kivistö, T. Kantola, P. J. Neuvonen, Different effects of itraconazole on the pharmacokinetics of fluvastatin and lovastatin British Journal of Clinical Pharmacology. ,vol. 46, pp. 49- 53 ,(1998) , 10.1046/J.1365-2125.1998.00034.X