Rhabdomyolysis induced by simvastatin and ketoconazole treatment.

摘要: Rhabdomyolysis is described as an adverse event of simvastatin therapy either by itself or in combination with other medications. It unclear whether this phenomenon specific to all cholesterol-lowering agents single-dose caused the association special coadministered We describe two cases which rhabdomyolysis developed after coadministration (20 mg/d) and antifungal ketoconazole. The clinical features, blood examination results, positive outcome were very similar both cases. concluded that ketoconazole, sterol synthetic inhibitor azol group, may induce patients undergoing treatment simvastatin, a lipid lowering agent, increase possibility muscle-damaging events agents.