Diagnosis of HIV-Associated Oral Lesions in Relation to Early versus Delayed Antiretroviral Therapy: Results from the CIPRA HT001 Trial

摘要: Oral mucosal lesions that are associated with HIV infection can play an important role in guiding the decision to initiate antiretroviral therapy (ART). The incidence of these relative timing ART initiation has not been well characterized. A randomized controlled clinical trial was conducted at GHESKIO Center Port-au-Prince, Haiti between 2004 and 2009. 816 HIV-infected ART-naive participants CD4 T cell counts 200 350 cells/mm3 were either immediate (early group; N = 408), or when count less than equal development AIDS-defining condition (delayed 408). Every 3 months, all underwent oral examination. 4.10 early group 17.85 delayed (p-value <0.01). In comparison group, there a significantly higher candidiasis, hairy leukoplakia, herpes labialis, recurrent simplex group. warts 0.97 before 4.27 post-ART seen (4.27 versus 1.09; p-value increased after initiated, four-fold increase if initiated following AIDS diagnosis. Based upon our findings, indicate immune suppression need start ART. contrast, sign reconstitution initiation.