摘要: Germline DNA (e.g., blood, mouthwash) is the most readily accessible source of material for identification pharmacogenetic markers therapy selection. However, cancer genome altered by many processes that could affect expression functional alleles in tumor. Consequently utility germline to predict tumor under question. Studies have suggested strong concordance between and genotype profiles markers. only one factor involved response chemotherapy mechanisms such as chromosome amplification loss, copy number variation, microsatellite instability, instability epigenetic variation (methylation) need be taken into account.
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Ingrid Becker, K F Becker, MH Röhrl, Gunter Minkus, K Schütze, H Höfler, None, Single-cell mutation analysis of tumors from stained histologic slides. Laboratory Investigation. ,vol. 75, pp. 801- 807 ,(1996)
Chikako Ito, Masa-aki Kumagai, Atsushi Manabe, Elaine Coustan-Smith, Susana C. Raimondi, Frederick G. Behm, K. Gopal Murti, Jeffrey E. Rubnitz, Ching-Hon Pui, Dario Campana, Hyperdiploid Acute Lymphoblastic Leukemia With 51 to 65 Chromosomes: A Distinct Biological Entity With a Marked Propensity to Undergo Apoptosis Blood. ,vol. 93, pp. 315- 320 ,(1999) , 10.1182/BLOOD.V93.1.315
Won-Seok Jo, John M. Carethers, Chemotherapeutic implications in microsatellite unstable colorectal cancer Cancer Biomarkers. ,vol. 2, pp. 51- 60 ,(2006) , 10.3233/CBM-2006-21-206
Sharon Marsh, Judith McKay, Stephanie Curran, G. Murray, James Cassidy, Howard McLeod, Primary colorectal tumour is not an accurate predictor of thymidylate synthase in lymph node metastasis Oncology Reports. ,vol. 9, pp. 231- 234 ,(2002) , 10.3892/OR.9.2.231
Howard L McLeod, Sharon Marsh, Pharmacogenetics goes 3D. Nature Genetics. ,vol. 37, pp. 794- 795 ,(2005) , 10.1038/NG0805-794
Attasit Boonsong, Sharon Marsh, Patrick H Rooney, David A.J Stevenson, James Cassidy, Howard L McLeod, Characterization of the Topoisomerase I Locus in Human Colorectal Cancer Cancer Genetics and Cytogenetics. ,vol. 121, pp. 56- 60 ,(2000) , 10.1016/S0165-4608(00)00242-9
Federico Cappuzzo, Fred R. Hirsch, Elisa Rossi, Stefania Bartolini, Giovanni L. Ceresoli, Lynne Bemis, Jerry Haney, Samir Witta, Kathleen Danenberg, Irene Domenichini, Vienna Ludovini, Elisabetta Magrini, Vanesa Gregorc, Claudio Doglioni, Angelo Sidoni, Maurizio Tonato, Wilbur A. Franklin, Lucio Crino, Paul A. Bunn, Marileila Varella-Garcia, Epidermal Growth Factor Receptor Gene and Protein and Gefitinib Sensitivity in Non–Small-Cell Lung Cancer Journal of the National Cancer Institute. ,vol. 97, pp. 643- 655 ,(2005) , 10.1093/JNCI/DJI112
Annette Staebler, Bianca Karberg, Juliane Behm, Petra Kuhlmann, Ulrike Neubert, Hartmut Schmidt, Eberhard Korsching, Horst Bürger, Ralph Lelle, Ludwig Kiesel, Werner Böcker, Ie-Ming Shih, Olaf Buchweitz, Chromosomal losses of regions on 5q and lack of high‐level amplifications at 8q24 are associated with favorable prognosis for ovarian serous carcinoma Genes, Chromosomes and Cancer. ,vol. 45, pp. 905- 917 ,(2006) , 10.1002/GCC.20356
Jill Kolesar, Stuart Pritchard, Keith Kerr, Kyungman Kim, Marianne Nicolson, Howard McLeod, Evaluation of NQO1 gene expression and variant allele in human NSCLC tumors and matched normal lung tissue. International Journal of Oncology. ,vol. 21, pp. 1119- 1124 ,(2002) , 10.3892/IJO.21.5.1119
Susana C. Raimondi, Yinmei Zhou, Susan Mathew, Sheila A. Shurtleff, John T. Sandlund, Gaston K. Rivera, Frederick G. Behm, Ching-Hon Pui, Reassessment of the prognostic significance of hypodiploidy in pediatric patients with acute lymphoblastic leukemia Cancer. ,vol. 98, pp. 2715- 2722 ,(2003) , 10.1002/CNCR.11841