Evaluation of NQO1 gene expression and variant allele in human NSCLC tumors and matched normal lung tissue.

摘要: NQO1 gene expression was evaluated by RT-PCR and SNP status RFLP in matched samples of lung tumors adjacent normal tissue. found to be overexpressed when compared The mean tissue 28.26 x 10(-14) ng/microl +/- 44.9 SD 61.46 103.2 tumors. higher the tumor than 27/50 (59%) patients (p=0.014). In samples, 25 (50%) were wild-type, 16 heterozygotes (32%) 8 had (16%). 14 wild-type (28%), heterozygous 19 (38%) (p=0.0043). genomic mutation associated with survival a pilot study stage II/III NSCLC patients. Patients homozygous genotype significantly shorter (median 12 months), or 41 months) (p=0.007), suggesting may important chemosensitivity as well pathogenesis cancer genotyping useful component pharmacogenetic strategies for treatment NSCLC.