Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by α-helical antimicrobial and cell non-selective membrane-lytic peptides

作者: Yechiel Shai

DOI: 10.1016/S0005-2736(99)00200-X

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摘要: Permeation of the cell membrane leading to death is a mechanism used by large number membrane-lytic peptides. Some are linear, mostly helical, and others contain one or more disulfide bonds forming beta-sheet both alpha-helix structures. They all soluble in solution but when they reach target membrane, conformational changes occur which let them associate with lyse membrane. lytic peptides not cell-selective different microorganisms normal mammalian cells, while specific either type cells. Despite extensive studies, mode action fully understood basis for their selectivity towards cells known. Many studies have shown that peptide-lipid interactions permeation play major role activity. Membrane amphipathic alpha-helical has been proposed via two general mechanisms: (i) transmembrane pore formation 'barrel-stave' mechanism; (ii) destruction/solubilization 'carpet' mechanism. This review, focused on stages induced representatives antimicrobial non-selective distinguishes between mechanism, holds versus

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