All-D-magainin : chirality, antimicrobial activity and proteolytic resistance
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DOI: 10.1016/0014-5793(90)81351-N
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摘要: Abstract All-D-magainin-2 was synthesized to corroborate experimentally the notion that biological function of a surface-active peptide stems primarily from its unique amphiphilic α -helical structure. Indeed, exhibited antibacterial potency nearly identical all-L-enantiomer. Being highly resistant proteolysis and non-hemolytic all-D-magainin might have considerable therapeutic importance.
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